SCIENTIFIC REFERENCES
Link N Suppresses Interleukin-1β-Induced Biological Effects on Human Osteoarthritic Cartilage
Alaqeel M et al. European Cells and Materials Vol. 39 2020 (pages 65-76) DOI: 10.22203/eCM.v039a04
Short Link N Acts as a Disease Modifying Osteoarthritis Drug
Antoniou J et al. European Cells and Materials Vol. 37 2019 (pages 347-359) DOI: 10.22203/eCM.v037a21
Link N as a Therapeutic Agent For Discogenic Pain
Noorwali H et al. JOR Spine. 2018;1:e1008
Short Link N Promotes Disc Repair in a Rabbit Model of Disc Degeneration
Mwale F et al. Arthritis Research & Therapy (2018) 20:201
Link N is Cleaved by Human Annulus Fibrosus Cells Generating a Fragment with Retained Biological Activity
Gawri R et al. J Orthopedic Research Month 2014 DOI 10.1002/jor.22653
Best Paper Nass 2013: Link-N Can Stimulate Proteoglycan Synthesis in the Degenerated Human Intervertebral Discs
Gawri R et al. European Cells and Materials Vol. 26 2013 (pages 107-119) DOI: 10.22203/eCM.v026a08
The Effect of Link N on Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells
Antoniou J et al. Arthritis Research & Therapy 2012, 14:R267
The Efficacy of Link N as a Mediator of Repair in a Rabbit Model of Intervertebral Disc Degeneration
Mwale F et al. Arthritis Research & Therapy 2011, 13:R120
ISSLS Prize winner: Effect of Link Protein Peptide on Human Intervertebral Disc Cells
Wang Z et al. Spine 2013 Aug 1;38(17):1501-7. doi: 10.1097/BRS.0b013e31828976c1
Link Protein N-terminal Peptide Binds to Bone Morphogenetic Protein (BMP) Type II Receptor and Drives Matrix Protein Expression in Rabbit Intervertebral Disc Cells
Wang Z et al. J Biol Chem. 288, No. 39, pp. 28243–28253, 2013 DOI 10.1074/jbc.M113.451948